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Starting a topical D3 cream that provides 1000 units per application so I will do this once daily. Approximately how long will it take for my D levels to increase?

General Discussion

Asked by  JayParish11682300 on December 2, 2015


  • JayParish11682300
     JayParish11682300 on

    See title

    Answered by  JayParish11682300 on

  • IAW
     IAW on

    There is not really any information on topical D3 creams and if they raise blood levels or not. So I really do not know. Did you get your Vitamin D level checked so you have a starting number? It is such a small amount, the 1000iu, that even if it absorbs you may not see much of a change if you retested your levels in let’s say 6-8 weeks.

    Answered by  IAW on

  • hlahore@gmail.com
     hlahore@gmail.com on

    1,000 IU is a very small amount.
    You can see the dose/response equations from many studies at
    Some people get ZERO increase in vitamin D levels from 1,000 IU
    It appears, however, that topical vitamin D results in perhaps a 2X response over that of oral vitamin D. http://vitamindwiki.com/tiki-index.php?page_id=5218

    Answered by  hlahore@gmail.com on

  • Amoll05079300
     Amoll05079300 on

    I’ve tried a 10 000 ie d3 cream, yes 10k!. To my own conclusion i think it even lowered my levels, because i felt sluggish as the time before i started my supplementation of d3. Even a guy who tried it himself had his levels checked up and they were lowered. The reason why it’s because:

    ” Vitamin D, as either D3 or D2, does not have significant biological activity. Rather, it must be metabolized within the body to the hormonally-active form known as 1,25-dihydroxycholecalciferol. This transformation occurs in two steps ”

    1. Within the liver, cholecalciferal is hydroxylated to 25-hydroxycholecalciferol by the enzyme 25-hydroxylase.
    2. Within the kidney, 25-hydroxycholecalciferol serves as a substrate for 1-alpha-hydroxylase, yielding 1,25-dihydroxycholecalciferol, the biologically active form.

    The transdermal solution with a d3 cream will bypass the liver which is required to be converted to the active form. It will store amounts of d3 inactive in your gut, which you can’t utilize. A pill will have it’s path through the kidney as it’s actually needed for your body to have d3 utilized. The only good thing it gave me was the magnesium which isn’t a problem with topical use. However mineral oils can increase the need for more d3 in your body.
    My suggestion and usually everyone elses: Use a well known brand of d3 supplements with a liquid emulsion/softgel having either olive oil/coconut oil in it.

    • This reply was modified 2 years, 1 month ago by  Amoll05079300.
    • This reply was modified 2 years, 1 month ago by  Amoll05079300.
    • This reply was modified 2 years, 1 month ago by  Amoll05079300.
    Answered by  Amoll05079300 on