VDC test kit slider
VDC test kit slider
sperti logo 1
Text size A A A
High contrast on off

Information on the latest vitamin D news and research.

Find out more information on deficiency, supplementation, sun exposure, and how vitamin D relates to your health.

Vitamin D levels: Associated with dry eyes?

New research published in the journal Cornea has raised the possibility that vitamin D plays a role in dry eye syndrome.

Dry eye syndrome is a prevalent condition characterized by the eye’s lack of ability to maintain a healthy coating of tears. While not a severe condition, it is a nuisance.

No studies to date have evaluated the effect of vitamin D levels on dry eye syndrome. However, one study did find that patients with Sjogren’s syndrome have lower vitamin D levels. Sjogren’s syndrome is an autoimmune disease characterized, in part, by dry eyes.

The researchers recruited 247 patients from the Miami Veterans Affairs eye clinic. They surveyed the patients about dry eyes [called the Dry Eye Questionnaire (DEQ5)]. The researchers also took blood samples for vitamin D levels.

The researchers wanted to know, do vitamin D levels correlate with dry eye syndrome? Here’s what they found:

  • Vitamin D levels were not significantly associated with many dry eye syndrome parameters, including presence of disease or disease severity.
  • However, vitamin D levels did correlate with dry eye syndrome symptoms. For every 10 ng/ml increase in vitamin D levels, there was a quantifiable drop in the scale ratings in the dry eye syndrome symptom questionnaire (the DEQ5).

The researchers reached mixed conclusions:

“Although we did find a positive effect of vitamin D levels on dry eye syndrome symptoms, the effect was small and likely not clinically meaningful.”

However they also stated:

“Higher vitamin D levels had a small but favorable effect on DES symptoms.”

Future research is underway looking at this issue and should elucidate these mixed results. For example, the VITAL trial that is administrating vitamin D to 10,000 people and placebo to another 10,000 people is examining the incidence of dry eye disease in these groups. You can find full details of that portion of the VITAL study here.


Galor A et al. Effect of a Mediterranean Dietary Pattern and Vitamin D Levels on Dry Eye Syndrome. Cornea, 2014.

  About: Brant Cebulla

Brant Cebulla was a staff member for the Vitamin D Council from May 2011 to April 2014. He has keen interests in nutrition and exercise.

One Response to Vitamin D levels: Associated with dry eyes?

  1. Rita and Misty says:

    “In conclusion, we have demonstrated that corneal epithelial cells contain VDR and 1α-hydroxylase mRNA, and that there are significant vitamin D metabolite concentrations in both the aqueous and vitreous humor. In addition, we show that both 25(OH)D3 and 1,25(OH)2D3 can enhance cornea epithelial barrier function and vitamin D supplementation enhances corneal occludin expression.”


    (gotta love vitamin D…imo)