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Information on the latest vitamin D news and research.

Find out more information on deficiency, supplementation, sun exposure, and how vitamin D relates to your health.

The latest on vitamin D and inflammation

Preventing inflammation is all the rage. Dark chocolate, tea, pomegranate juice, berries, and vegetables are a few of the mainstays of an anti-inflammatory diet.

Habauzit V, Morand C. Evidence for a protective effect of polyphenols-containing foods on cardiovascular health: an update for clinicians. Ther Adv Chronic Dis. 2012 Mar;3(2):87-106

What about vitamin D and inflammation? Recently, Dr Uwe Querfeld of the Charité Children’s Hospital in Germany reviewed the world’s literature on vitamin D and inflammation.

Querfeld U. Vitamin D and inflammation. Pediatr Nephrol. 2012 Dec 13

Dr. Querfeld found:

  1. “It has recently become evident that renal and cardiovascular disease often develops in parallel and influences each other. This has been described as cardio-renal syndrome.”
  2. CRP levels or C-reactive protein (a marker of inflammation) are an independent predictor of all-cause and cardiovascular mortality.
  3. “Subjects with low vitamin D levels and high CRP serum concentrations had the shortest leukocyte telomere length, indicating a higher cumulative burden of oxidative stress and inflammation.”
  4. Vitamin D inhibits the activation the TNF alpha converting enzyme, which has an important role in the generation of inflammation.
  5. Vitamin D also appears to control inflammation through regulation of the transcription factor NF-κB.
  6. “There is likely a whole spectrum of interrelated beneficial effects and potential mechanisms by which vitamin D may lower cardiovascular risk.”
  7. “Randomized controlled studies examining the effect of vitamin D administration on inflammatory markers and cardiovascular outcomes are clearly needed.”

Wait for randomized controlled trials if you want. As for me, I will continue to maintain natural vitamin D blood levels (50-60 ng/ml), while I wait for scientists to do their work.

  About: John Cannell, MD

Dr. John Cannell is founder of the Vitamin D Council. He has written many peer-reviewed papers on vitamin D and speaks frequently across the United States on the subject. Dr. Cannell holds an M.D. and has served the medical field as a general practitioner, emergency physician, and psychiatrist.

One Response to The latest on vitamin D and inflammation

  1. Rita and Misty says:


    “Inflammation is the common denominator of many chronic age-related diseases such as arthritis, gout, Alzheimer’s, and diabetes. But according to a Yale School of Medicine study, even in the absence of a disease, inflammation can lead to serious loss of function throughout the body, reducing healthspan — that portion of our lives spent relatively free of serious illness and disability.”