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Information on the latest vitamin D news and research.

Find out more information on deficiency, supplementation, sun exposure, and how vitamin D relates to your health.

Russian ecological study finds increase in cancer rates at higher latitudes

A paper published in March 2011 by Michael F. Borisenkov reported that a number of cancer rates increase significantly with increasing latitude in Russia. The cancers that increase in both incidence and mortality are esophageal, kidney, pancreatic, stomach cancer and melanoma. The cancers that increase just in incidence are bladder, colon, ovarian and rectal cancer. The cancers that increase just in mortality are acute myeloid leukemia, immunoproliferative diseases and multiple myeloma.

The authors explained the findings on a “hypothesis of circadian disruption.” Melatonin levels rise when blue light levels are lower, and melatonin helps induce sleep. As the length of daylight increases, less melatonin is produced. There is evidence that melatonin reduces the risk of cancers such as breast, colon, endometrial, ovarian, prostate, and rectal. However, it does not appear that latitudinal studies can be used to evaluate this hypothesis.

Most of these cancers have been found inversely correlated with solar ultraviolet-B (UVB) doses for July or annual UVB in the United States. Many have also been found to have rates that increase with latitude in Australia, China, France, Japan, and Spain. Thus, the paper by Borisenkov provides further evidence for the UVB-vitamin D-cancer hypothesis.

For melanoma cancer, UVB and vitamin D seem to play a role, but skin pigmentation does, too. Those living in their ancestral homelands at higher latitude have paler skin than those living at lower latitudes. Melanoma rates increase with latitude in Europe, but not in the United States. In the U.S., pale-skinned people live at all latitudes.

A better way to check the melatonin-cancer hypothesis through ecological studies is through the seasonality of cancer. Breast cancer has been found to progress more rapidly in spring and fall [Borisenkov, 2005]. There are also two peaks of diagnoses, one in spring, one in fall [Oh, 2010]. The two peaks have been explained as being related to vitamin D production in summer and melatonin production in winter [Oh, 2010].

 

References

Borisenkov MF. Latitude of residence and position in time zone are predictors of cancer incidence, cancer mortality, and life expectancy at birth. Chronobiol Int. 2011 Mar;28(2):155-62.

Borisenkov MF, Bazhenov SM. [Seasonal patterns of breast tumor growth in Far North residents]. Vopr Onkol. 2005;51(6):708-11. Russian.

Oh EY, Ansell C, Nawaz H, Yang CH, Wood PA, Hrushesky WJ. Global breast cancer seasonality. Breast Cancer Res Treat. 2010 Aug;123(1):233-43.

  About: Dr William Grant

Dr. William Grant is an epidemiologist and founder of the nonprofit organization Sunlight, Nutrition and Health Research Center (SUNARC). He has written over 140 peer-reviewed articles and editorials on vitamin D and health. Dr. Grant is the Science Director of the Vitamin D Council and also serves on their Board. He holds a Ph.D. in Physics from UC Berkeley.

4 Responses to Russian ecological study finds increase in cancer rates at higher latitudes

  1. Brant Cebulla says:

    See our cancer summaries written by Dr. William Grant in our Health Conditions section: http://www.vitamindcouncil.org/health-conditions/cancer/

  2. JBG says:

    “Melatonin levels rise when blue light levels are higher…”
    My understanding was(is) that blue light suppresses melatonin production…

  3. My mistake:
    The statement: Melatonin levels rise when blue light levels are higher, and melatonin helps induce sleep. is incorrect.

    The correct statement is: Melatonin levels rise when blue light levels are lower, and melatonin helps induce sleep.

  4. Brant Cebulla says:

    Post edited September 21, 2011 at 3:03* to make the aforementioned correction.