A new study published in British Medical Journal used Mendelian randomization to discover that genetically low vitamin D levels were related to increased all-cause mortality, cancer mortality, and other mortality, but not cardiovascular mortality.
Mendelian randomization is a unique type of study design which examines how genes that are associated with certain health markers affect physical traits. We covered this design in a previous blog.
Vitamin D has been associated with increased all-cause, cardiovascular, and cancer mortality in observational research. However, the randomized intervention trials that have examined the relationship between vitamin D supplementation and mortality have not provided clear support for a role of vitamin D in mortality.